Congress Organisers

Coenraad Hendriksen, Institute for Translational Vaccinology (Intravacc), NL
Catrina Stirling, Zoetis, UK
Ian Ragan, NC3Rs, UK

Information

  • Language The official language of the Congress is English
  • Climate The average temperature in September is around 14.50C.
  • Liability & Insurance The Congress Secretariat and Organisers cannot accept liability for personal accidents or loss of or damage to private property of participants and accompanying persons. Participants are advised to take out their own personal travel and health insurance for their trip.
  • Visas Participants are requested to check with the Consulate/Embassy of the Netherlands or diplomatic mission in their home country or with their travel agency for visa requirements. It is the responsibility of the participant to obtain a visa if required.
  • Letter of Invitation Upon request, the Congress Secretariat will send personal invitation letters to participants. This invitation is prepared solely for the purpose of visa applications and is not a commitment on the part of the organizers to provide any financial support or confirmation of inclusion in the Scientific Program. Please email your request with full name, postal address and passport number to: Consistencycongress-IABS@intravacc.nl. Invitation letters can be provided electronically (PDF) or as a hard copy if required. Hard copies will be mailed via regular post free of charge. In case of special delivery (courier) request, the participant will be responsible for all charges.
  • Congress Organisers Please do not hesitate to contact the Organisers if you require any additional information or assistance. Please address all correspondence to:
    Consistencycongress-IABS@intravacc.nl or iabs@iabs.org

Local Organising Committee

  • Arnoud Akkermans (RIVM)
  • Johan van der Gun (Bbio)
  • Marieke Hoonakker (Intravacc)
  • Gideon Kersten (Intravacc)
  • Fabrizio de Mattia (MSD)
  • Bernard Metz (Intravacc)

Scientific Committee

  • Juan Arcieniega (FDA)
  • Lukas Bruckner (IVI)
  • Karl-Heinz Buchheit (EDQM)
  • David Dusek (USDA)
  • Marlies Halder (EURL-ECVAM)
  • Richard Isbrucker (Health Canada)
  • Suresh Jadav (SII)
  • Carmen Jungbeck (PEI)
  • Laurent Mallet (Sanofi-Pasteur)
  • Eddy Rommel (Rommel Consulting Partners)
  • Thea Sesardic (NIBSC)
  • Rebecca Sheets (IABS)

Provisional Programme

IABS Conference ‘3Rs Alternatives and Consistency Testing in Vaccine Lot Release Testing’

Wednesday, September 16, 2015

From 10.30am on registration open, coffee available
12.00 – 13.00 Lunch (buffet) in restaurant
13.00 - 13.30 Opening of conference (Lamoraalzaal)
13.00 – 13.05 - John Petricciani, chairman IABS
13.05 – 13.10 - Rob van Zeeland, CEO Intravacc
13.10 – 13.30 - Hans van Dongen (Ministry Economic Affairs, NL) with video welcome from State Secretary Mrs.Sharon Dijksma, Ministry of Economic Affairs, NL
13.30 – 17.25 Session 1: Opportunities and barriers in 3Rs alternatives
13.30 – 13.55 The historical context (Coenraad Hendriksen, Intravacc, NL)
13.55 – 14.20 Time to apply 3 Rs to virus testing? (Rebecca Sheets, Grimalkin Partners, USA)
14.20 – 14.45 Waiving the target animal batch safety test at MSD Animal Health (Harrie Glansbeek, MSD Animal Health, NL)
14.45 – 15.10 Waiving of abnormal toxicity testing(Klaus Cussler, Paul Ehrlich Institut, D)
15.10 – 15.40 Coffee break
15.40 – 16.05 Feedback from the satellite meeting on harmonisation (Catrina Stirling, Zoetis, UK)
16.05 – 16.30 BSP130: Validation of cell line assays for in-process testing of Clostridium septicum vaccine antigens (Keith Redhead, chair EPAA clostridial toxoids working group, UK)
16.05 – 16.30 Human Rabies vaccine potency testing; the test for G-protein : report of the pre-collaborative study and future strategies (Jean-Michel Chapsal, chair EPAA Rabies working group, F)
16.30 – 16.55 Regulatory acceptance and use of 3R models in rabies vaccines quality control (Marie-Jeanne Schiffelers, USBO- Utrecht University, NL)
16.55 - 17.10 Viral safety of vaccines: how to streamline the Adventitious Testing Package? (Laurent Mallet, Sanofi Pasteur, F)
17.10 – 17.25 A competition ELISA for potency testing of equine anti rabies sera as an alternative assay for theMouse Neutralisation test (Sylvie Morgeaux, Agence Nationale de Sécurité du Médicament et des Produits de Santé, F)
18.30 – 19.30 Get together in The Pub
19.30 - Dinner (buffet) in restaurant

Thursday, September 17, 2015

08.30 – 08.50 Proteomic analysis of bovine tuberculin purified derivates (Elisabeth Balks, Paul Ehrlich Institut, D)
08.50 – 09.20 Alternative method for Rabies Immunoglobulin Mouse Potency testing (Emmanuelle Coppens, Sanofi Pasteur, F)
09.20 – 12.30 Session 2 Consistency Approaches
09.20 – 09.40 Evolution of veterinary vaccines – an industry perspective on consistency (Vaughn Kubiak, Zoetis, BE)
09.40 – 10.00 What we talk about when we talk about Replacement (Juan Arciniega, FDA, USA)
10.00 – 10.20 The Ph.Eur.’s stance on consistency testing and 3Rs (Karl-Heinz Buchheit, EDQM, F)
10.20 – 10.40 WHO’s position on 3Rs and consistency testing (provisional title) Dialiang Lei, WHO, CH)
10.40 – 10.50 Coffee break
10.50 – 11.15 The use of production platforms in vaccine manufacturing (Jody French, Harris Vaccines, USA)
11.15 – 11.40 Antigenic fingerprinting of diphtheria toxoid adsorbed to alum based adjuvants (Gideon Kersten, Intravacc, NL)
11.40 – 12.05 A model of the human artificial lymph node (HuALN) for testing biopharmaceuticals and vaccines (Christoph Giese, ProBiogen, D)
12.05 – 12.30 Use of physico-chemical methods for consistency testing (John Hoogerheide, Zoetis, US)
12.30 -13.30 Lunch (walking lunch outside the Lamoraalzaal)
13.30 – 13.50 Functional in vitro testing of vaccines within the consistency approach: a proof-of-principle using whole cell Bordetella pertussis vaccine (Marieke Hoonakker, Intravacc, NL)
13.50 – 14.15 3Rs and consistency testing in emerging economies : progress and global expectations (Nora Dellepiane, Serum Institute of India, India)
14.15 – 14.35 Moving towards consistency approach for Diphtheria Tetanus Pertussis potency assays (Sylvie Uhlrich, Sanofi Pasteur, F)
14.35 – 14.55 Diphtheria and consistency testing: the results of a comparison study (Bernard Metz, Intravacc, NL)
14.55 – 15.30 Coffee break
15.30 – 18.00
  • Session 3 : Workshops (parallel)
  • Workshop 1: 3Rs alternatives* (Chair: Lukas Bruckner, IVI, CH)
  • Workshop 2: Consistency testing** (organised by National Institute for Public Health and the Environment (RIVM))>/b>
19.30 - Conference Dinner

* Members Panel : Lukas Bruckner (chairman), Marlies Halder (EURL-ECVAM, I), Perceval Sondag, (Arlenda), Laurent Mallet (Sanofi Pasteur, F), Marie-Jeanne Schiffelers (UU, NL), Keith Redhead , UK and Juan Arciniega (FDA, USA)

** Moderators : Carmen Jungbaeck (PEI, D), Laura Viviani (GSK, CH), Eddy Rommel, (Rommel Consulting Partners,B), Ton van der Stappen (MEB, NL), Ian Ragan (NC3Rs, UK)

Friday, September 18, 2015

09.00 – 09.25 The promise and perils of complex data analysis (Stanley Deming, Statistical Designs, USA)
09.25 – 09.50 Comparison and bridging of bioassays: doing more with less using Bayesian statistics (Perceval Sondag, Arlenda, B)
09.50 – 10.15 Use of Risk Assessment to effect replacements of animal-based toxicity tests for vaccines by in vitro tests (Blaise Descampe, GSK, B)
10.15 – 11.00 Coffee break
11.00 – 13.00 Session 4: The way forward
11.00 – 12.00 Feed back from workshops
12.00 – 12.30 The way forward (Catrina Stirling, Zoetis, UK & Ian Ragan, NC3Rs, UK)
12.30 – 12.45 Take home message (Karl-Heinz Buchheit, EDQM, F)
12.45 Closure of conference (Coenraad Hendriksen, Intravacc, NL)
13.00 Lunch (buffet in restaurant)